Nitrogen → 1-Phenyl-1-propanol

Participants

Reaction Steps

12.2 mg (2×10-5 moles) of [Ir(PPEI)COD]+ClO4- (+) were suspended in 50 ml of isopropanol and oxidized with air for 4 hours. The yellow limpid solution so obtained was degasified for 20 minutes at reflux under a nitrogen stream and then treated with 2.7 ml of a deaerated isopropanol solution of KOH (2 mg of KOH). The solution was preliminarily reduced for 30 minutes in a N2 stream at reflux and then treated with 2.56 ml of deaerated propiophenone. After 60 minutes the reaction was stopped, obtaining a conversion to phenylpropanol (+) of 57.3% with an e.e. of 30%. Ratios:

Provenance & Evidence