1-Phenyl-1-propanone → 1-Phenyl-1-propanol

Participants

Reaction Steps

12.2 mg (2×10-5 moles) of [Ir(PPEI)COD]+ClO4- (+) were suspended in 50 ml of isopropanol and oxidized with air for 4 hours. The resulting solution was degasified for 20 minutes at reflux in N2 and then treated with 4.5 ml of a deaerated isopropanol solution of KOH (8 mg of KOH). The solution, after a preliminary 30-minute reduction in a nitrogen stream, was treated with 2.56 ml of deaerated propiophenone. After a 120-minute reaction, a conversion to phenylpropanol (+) of 93.3% with an e.e. of 26.1% was obtained. Ratios:

Provenance & Evidence