1-Phenyl-1-propanone → 1-Phenyl-1-propanol

Participants

Reaction Steps

6.1 mg (1×10-5 moles) of [Ir(PPEI)COD]+ClO4- (+) were suspended in 50 ml of isopropanol and oxidized with air for 4 hours. The yellow solution obtained was then degasified at reflux in a nitrogen stream for 20 minutes and then treated with 4.0 ml of an isopropanol solution of KOH (4 mg of KOH). The solution, after a preliminary reduction for 30 minutes at reflux in a nitrogen flow, was treated with 2.56 ml of deaerated propiophenone. After 180 minutes, a conversion to phenylpropanol (+) of 89.3% with an e.e. of 26.1% was obtained. Ratios:

Provenance & Evidence