Methyl iodide → HCID 178503870, compound

HRID 1578045Notes

Reaction equation

HRID 1578045 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:15])[CH3:14])=[S:11].[OH-].[K+].[CH3:18]I>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[N:12][C:13](=[O:15])[CH3:14])[S:11][CH3:18]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 12952276HCID 12952276, compound

Product 1

HCID 178503870HCID 178503870, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

26.3 g (0.1 M) of N-(2,6-dichlorophenyl)-N'-acetylthiourea, 8.1 g (0.12 M as 100%) of potassium hydroxide, 7.7 ml (0.12 M) of methyliodide and 250 ml of ethanol are mixed and are heated in a water bath at 50°-60° for 5 hours. The ethanol is distilled off. The residue in the flask is washed with water and filtered. After recrystallization from isopropanol 14.0 g (50.5 % of the theoretical yield) of N-(2,6 -dichlorophenyl)-N'-acetyl-S-methylisothiourea are isolated.

Workup

  1. temperatureare heated in a water bath at 50°-60° for 5 hours
  2. distillationThe ethanol is distilled off
  3. washThe residue in the flask is washed with water
  4. filtrationfiltered
  5. customAfter recrystallization from isopropanol 14.0 g (50.5 % of the

Sources & evidence

ORD record
ord-2219f054f25645879382cedd89156cd6
Source dataset
uspto-grants-1981_09
Patent number
US04290971

Reaction notes

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