反应详情

温度

80 °C

A solution of 3.46 g of 2,3,6,7-tetrachloroquinoxaline in 200 ml of ethanol was saturated with ammonia at 0° C. and was then shaken overnight at 80° C. under pressure in a Cook Hydrogenator. The solution was evaporated to dryness and the residue was triturated with water to obtain a buff crystalline solid. The latter was chromatographed over silica gel and was eluted with a 1-1 ethyl acetate-petroleum ether (b.p.=60° to 80° C.) mixture to obtain 1.36 g of 2-amino-6,7-dichloro-3-ethoxy-quinoxaline melting at 191°-193° C.

1. customThe solution was evaporated to dryness
2. customthe residue was triturated with water
3. customto obtain a buff crystalline solid
4. customThe latter was chromatographed over silica gel
5. washwas eluted with a 1-1 ethyl acetate-petroleum ether (b.p.=60° to 80° C.) mixture