N,N-Dimethyl-1,3-propanediamine → 7-Chloro-1-[3-(dimethylamino)propyl]imino-10-hydroxy-3-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydroacridin-9(10H)-one

関与物質

反応手順

To 2.3 g of 7-chloro-3,4-dihydro-10-hydroxy-3-[4-(trifluoromethyl)phenyl]-1,9(2H,10H)-acridinedione in 55 ml of ethanol is added 0.70 g of N,N-dimethyl-1,3-propanediamine in 5 ml of ethanol. The solution is heated to reflux and then allowed to cool to room temperature. The solvent is removed in vacuo and the residue is recrystallized from a mixture of benzene and cyclohexane to give 7-chloro-1-[[3-(dimethylamino)propyl]imino]-1,3,4,10-tetrahydro-10-hydroxy-3-[4-(trifluoromethyl)phenyl]9(2H)-acridinone; mp 130°-135° C.

情報源と証拠