HCID 20568900, compound → HCID 20568894, compound

HRID 1578117Notes

Reaction equation

HRID 1578117 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH2:16][CH2:15]1)[C:7]2=[O:30])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([CH:14]1[CH2:15][CH2:16][N:17]([CH2:20][C:21]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[NH:23][CH:22]=3)[CH2:18][CH2:19]1)[C:7]2=[O:30]

Participants

4

Reactant 1

HCID 20568900HCID 20568900, compound

Product 1

HCID 20568894HCID 20568894, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Nitro-2-[1-(indol-3-ylmethyl)piperid-4-yl]-1H-isoindole-1,3-(2H)-dione (0.8 g, 1.98 mmol) was hydrogenated in methanol over Pd/C (5%, 0.15 g) at atmospheric pressure. The catalyst was filtered off and the filtrate evaporated. The solid product was recrystallised from chloroform to give the title compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customThe solid product was recrystallised from chloroform

Sources & evidence

ORD record
ord-f1543f7dd8c14ce3925888dd28a2c991
Source dataset
uspto-grants-1981_09
Patent number
US04291042

Reaction notes

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