4-Acetylthiobutyroyl chloride → (2S)-1-[4-(acetylthio)-1-oxobutyl]-2,5-dihydro-4-[(4-methyl)phenyl]-1H-pyrrole-2-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	4-Acetylthiobutyroyl chloride	HCID 20428487	—
Reactant	1-[4-(Acetylthio)-1-oxobutyl]-4-hydroxy-4-[(4-methyl)phenyl]-L-proline	HCID 22817492	—
Reactant	N-carbobenzyloxy-4-hydroxy-4-[(4-methyl)phenyl]-L-proline	HCID 22817588	—
Product	(2S)-1-[4-(acetylthio)-1-oxobutyl]-2,5-dihydro-4-[(4-methyl)phenyl]-1H-pyrrole-2-carboxylic acid	HCID 57161405	—

Reaction Steps

The 3,4-dehydro-4-[(4-methyl)phenyl]-L-proline from part (a) is reacted with 4-acetylthiobutyroyl chloride according to the procedure of Example 3 (b) to yield (2S)-1-[4-(acetylthio)-1-oxobutyl]-2,5-dihydro-4-[(4-methyl)phenyl]-1H-pyrrole-2-carboxylic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04291040
Source dataset	uspto-grants-1981_09
ORD ID	ord-490ef3a585fc444da9af1c104389064c
Source note	uspto-grants-1981_09