Sodium Hydroxide → [6,7-Dichloro-1-oxo-2-(p-chlorophenyl)-2-propargyl-5-indanyloxy]acetic Acid

HRID 1578174Notes

Reaction equation

HRID 1578174 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)([CH2:13][C:14]#[C:15][Si](C)(C)C)[C:8]2=[O:12])=[CH:4][C:3]=1[O:27][CH2:28][C:29]([O:31]CC)=[O:30].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)([CH2:13][C:14]#[CH:15])[C:8]2=[O:12])=[CH:4][C:3]=1[O:27][CH2:28][C:29]([OH:31])=[O:30]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12774093Ethyl [6,7-dichloro-1-oxo-2-(p-chlorophenyl)-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate

Product 1

HCID 12774095[6,7-Dichloro-1-oxo-2-(p-chlorophenyl)-2-propargyl-5-indanyloxy]acetic Acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Desilylation and hydrolysis of ethyl [6,7-dichloro-1-oxo-2-(p-chlorophenyl)-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate with sodium hydroxide in ethanol according to the procedure of Example 1, STEP (c), affords the title compound, m.p. 200°-201°.

Sources & evidence

ORD record
ord-a2cfc4881de944bbb79b9111228b5a53
Source dataset
uspto-grants-1981_09
Patent number
US04291168

Reaction notes

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