Sodium Hydroxide → (6,7-Dibromo-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic Acid

HRID 1578175Notes

Reaction equation

HRID 1578175 reaction equation
[Br:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([CH2:13][C:14]#[C:15][Si](C)(C)C)[C:8]2=[O:12])=[CH:4][C:3]=1[O:26][CH2:27][C:28]([O:30]CC)=[O:29].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)([CH2:13][C:14]#[CH:15])[C:8]2=[O:12])=[CH:4][C:3]=1[O:26][CH2:27][C:28]([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13065300Ethyl [6,7-dibromo-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate

Product 1

HCID 13065302(6,7-Dibromo-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic Acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Desilylation and hydrolysis of ethyl [6,7-dibromo-1-oxo-2-phenyl-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate with sodium hydroxide in ethanol according to the procedure of Example 1, STEP (c), affords the title comound.

Workup

  1. customaffords the title comound

Sources & evidence

ORD record
ord-3ebf5ebb174e49e08f4f6d7bd6234be8
Source dataset
uspto-grants-1981_09
Patent number
US04291168

Reaction notes

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