Trifluoroacetic acid → HCID 131712426, compound

Participants

Reaction Steps

In this Example, 280 mg. (0.59 mmole) of (±)-cis-7-[(R)-2-phenyl-2-t-butyloxycarbonylaminoacetamido]-2-t-butyloxycarbonyl-1-azabicyclo[4,2,0]oct-2-en-8-one obtained in Example 25 is dissolved in 2.5 ml of anhydrous methylene chloride and 2.5 ml of anisole, and 5.0 ml of trifluoroacetic acid is added under ice cooling. The mixture is allowed to stand for 4 hours and 50 minutes under ice cooling and is then concentrated. To the concentrated residue, 10 ml of ether is added and the mixture is stirred at room temperature for one hour to form a precipitate. The precipitate is collected by filtration to obtain 202 mg. (70.9%) of the desired compound as a pale yellow powder having the following properties.

Provenance & Evidence