Morpholine → HCID 12944898, compound

Participants

Reaction Steps

6,7-Dichloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (4.3 g) and morpholine (10 cm3) in DMSO (45 cm3) were heated for 3 hours at 110° C. under the same conditions as in Example 6. The reaction product crystallised on cooling. It was filtered off and recrystallised from 40 cm3 of a mixture of DMF (dimethylformamide; 1 volume) and methyl cellosolve (1 volume). 3.3 g of 6-chloro-1-ethyl-7-morpholino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 266° C., were obtained.

Provenance & Evidence