Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6,7-Dichloro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 12733886 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | HCID 12944899 | HCID 12944899 | — |
Reaction Steps
A solution of 4.3 g of 6,7-dichloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid and 5.5 cm3 of piperidine in a mixture of 20 cm3 of DMF and 20 cm3 of methyl cellosolve was heated for 5 hours at 110° C. After concentration of the solution in vacuo, the residue was taken up in 50 cm3 of isopropanol. The solid was filtered off and recrystallised from methyl cellosolve (50 cm3). 2.4 g of 6-chloro-1-ethyl-4-oxo-7-piperidino-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 230° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04292317 |
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| Source dataset | uspto-grants-1981_09 |
|---|
| ORD ID | ord-9df0188a946d41ddb2f1a2d888ff0c77 |
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| Source note | uspto-grants-1981_09 |
|---|
