Methane → HCID 12944903, compound

Participants

Reaction Steps

2.18 g of 6,7-dichloro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 3.5 cm3 of 1-methylpiperazine and 25 cm3 of dimethylsulphoxide were heated at 110° C. for 3 hours. The solvent was evaporated off in vacuo and the residue was taken up in 100 cm3 of water. The suspension was stirred and mixed with 20 cm3 of N sodium hydroxide solution. The solution obtained, which was slightly turbid, was stirred with animal charcoal and filtered, and then brought to pH 7.5 by the addition of acetic acid. The precipitate was filtered off, washed with water and then recrystallised from methyl cellosolve. 1 g of 6-chloro-1-methyl-7-(4-methylpiperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 286° C., were obtained.

Provenance & Evidence