Morpholine → HCID 12944917, compound

Participants

Reaction Steps

2.6 g of 7-chloro-6-fluoro-4-oxo-1-vinyl-1,4-dihydro-quinoline-3-carboxylic acid, 3.5 cm 3 of morpholine and 30 cm3 of dimethylsulphoxide were heated for 15 hours under reflux. The solvent was removed by distillation under reduced pressure and the residue was taken up in 20 cm3 of ethanol. The insoluble solid was separated and recrystallised from 8 cm3 of a 1:1 (by volume) mixture of methylcellosolve and ethanol. 0.4 g of 6-fluoro-7-morpholino-4-oxo-1-vinyl-1,4-dihydroquinoline-3-carboxylic acid, m.p. 218°-220° C., was obtained.

Provenance & Evidence