1-Methylpiperazine → HCID 12944919, compound

Participants

Reaction Steps

28 g of 7-chloro-6-fluoro-1-(2-hydroxyethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 40 g of 1-methyl piperazine and 200 cm3 of pyridine were heated for 18 hours under reflux. The solvent was removed by distillation under reduced pressure. The residue was taken up in 100 cm3 of water, the mixture was agitated and adjusted to pH 6.8 by the addition of acetic acid. The solid was filtered off, washed with water and recrystallised from DMF. 24 g of 6-fluoro-1-(2-hydroxyethyl)-7-(4-methyl-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, m.p. 270° C., were obtained.

Provenance & Evidence