HCID 12767988, compound → HCID 6398674, compound

HRID 1578302Notes

Reaction equation

HRID 1578302 reaction equation
[OH:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C:13]([O:23][CH3:24])([NH:14][C:15](=[O:22])[CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[C:12](=[O:25])[N:7]2[C:8]=1[C:9]([OH:11])=[O:10].ClC(Cl)(Cl)C[O:29][C:30]([N:32]=C=O)=O>>[C:30]([O:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C:13]([O:23][CH3:24])([NH:14][C:15](=[O:22])[CH2:16][C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[C:12](=[O:25])[N:7]2[C:8]=1[C:9]([OH:11])=[O:10])(=[O:29])[NH2:32]

Participants

3

Reactant 2

HCID 12767988HCID 12767988, compoundHCID 68543058HCID 68543058, compound

Product 1

HCID 6398674HCID 6398674, compound

Procedure

When 3-hydroxymethyl-7-methoxy-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid is reacted with 2,2,2-trichloroethoxycarbonyl isocyanate and the resulting imidodicarboxylate is deblocked following the procedures described in Example 5, 3-carbamoyloxymethyl-7-methoxy-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid is obtained.

Sources & evidence

ORD record
ord-393df387e5664c2b831a50c6a7383d77
Source dataset
uspto-grants-1981_09
Patent number
US04292427

Reaction notes

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