Formaldehyde → HCID 20568527, compound

Participants

Reaction Steps

To a suspension of 2.16 g (0.01 mol) of 1-phenyl-5-carbethoxyimidazole in 5 ml of water are added 0.8 g (0.02 mol) of sodium hydroxide and then 4 ml of ~37% aqueous formaldehyde. The mixture is heated at 80°-90° C. for 2 hours. The reaction mixture is concentrated in vacuo, and then the residue is extracted with ethyl acetate. The ethyl acetate extract is concentrated to give 1-phenyl-5-hydroxymethylimidazole as a solid, m.p. 81°-84° C.

Provenance & Evidence