Acetic Anhydride → [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-anilino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl acetate

Participants

Reaction Steps

In 100 parts by volume of pyridine is suspended 10 parts by weight of 2-phenylaminoinosine and 50 parts by weight of acetic anhydride is added dropwise. The mixture is stirred for 3 hours, at the end of which time it is concentrated under reduced pressure. The residue is recrystallized from 5 parts by volume of methanol. The procedure gives 2 parts by weight of 2-phenylamino-2',3',5'-tri-O-acetylinosine in the form of colorless flocs.

Provenance & Evidence