2-Amino-5-nitrobenzene-1,3-dicarbonitrile → HCID 21559844, compound

Participants

Reaction Steps

2,6-Dicyano-4-nitro-phenol, used in Example 12, was prepared according to generally known processes: 2,6-dicyano-4-nitro-aniline is converted by a Sandmeyer reaction into 2,6-dicyano-4-nitro-chlorobenzene of melting point 218°-219.5°C, reacted with methanol/sodium hydroxide to give 2,6-dicyano-4-nitro-anisole of melting point 144°-148°C, and the latter subsequently split with sodium iodide in dimethylformamide to give 2,6-dicyano-4-nitro-phenol of melting point 228°-231°C. The last two stages correspond to a process indicated in Belgian Pat. No. 764,117.

Provenance & Evidence