1-Butanol → HCID 21559906, compound

Participants

Reaction Steps

A reaction mixture containing 1.00 g (6.09 mmols) of 4,6-dichloro-5-aminopyrimidine, 1.22 g (7.30 mmols) of 3,4-dimethoxybenzylamine, 1.02 ml (7.30 mmols) of triethylamine and 35 ml of 1-butanol was refluxed overnight for 17 hours. Evaporation of the reaction mixture in vacuo gave a residual oil which was crystallized by trituration with water. The crude yellow solid was recrystallized from methanol-water to give 1.61 g (90.1%), mp 185°-188°, of crystalline product. The analytical sample was obtained by recrystallization from methanol-water; yield, 1.36 g (76.9%); mp 188°-191°.

Provenance & Evidence