HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 21559931, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | 3,4-Dimethoxybenzeneacetonitrile | HCID 66727 | — |
| Reactant | 4-Chloroquinoline | HCID 69140 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| Product | HCID 21559931 | HCID 21559931 | — |
| Product | HCID 21559932 | HCID 21559932 | — |
Reaction Steps
The process of this invention utilizing sodium amide in liquid ammonia is effective in promoting the condensation of 3,4-dimethoxyphenylacetonitrile with 4-chloroquinoline and 6,7-dimethoxy-4-chloroquinoline to furnish 4-veratrylquinoline and 6,7-dimethoxy-4-veratrylquinoline, respectively, after hydrolysis. The process of U.S. Pat. No. 2,568,778 issued Sept. 25, 1951, utilizing sodium amide in benzene is ineffective in promoting these condensations.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03936461 |
| Source dataset | uspto-grants-1976_02 |
| ORD ID | ord-f60e13f7536c432da0078378bfd068f0 |
| Source note | uspto-grants-1976_02 |