Acetic Anhydride → Actarit

HRID 1578396Notes

Reaction equation

HRID 1578396 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12][C:13](OC(C)=O)=[O:14]>>[C:13]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1)(=[O:14])[CH3:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 145334-Aminophenylacetic acid

Product 1

HCID 2018Actarit

Procedure

The mixture of 100 g (4-amino-phenyl)-acetic acid and 200 ml acetanhydride is heated at the steam cone for 15 minutes and evaporated. The residue is stirred with 500 ml hot water until complete dissolution occurs. The solution is cooled and the precipitate formed filtered off, to yield the (4-acetamido-phenyl)acetic acid melting at 168°-170°.

Workup

  1. temperatureis heated at the steam cone for 15 minutes
  2. customevaporated
  3. temperatureThe solution is cooled
  4. customthe precipitate formed
  5. filtrationfiltered off

Sources & evidence

ORD record
ord-1e27e3163bd441819ef879fb3c730091
Source dataset
uspto-grants-1976_02
Patent number
US03936467

Reaction notes

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