4-Phenylpiperidine → HCID 21559963, compound

Participants

Reaction Steps

A solution of 580 mg. (18.6 mmol) of 5-acetyl-6,7-dihydro-7-(2-bromoethyl)-5H-1,3-dioxolo[4,5-f]indole and 600 mg. (37.2 mmol) of 4-phenylpiperidine in 30 ml. of toluene is heated at reflux temperature for 18 hours. The solvent is removed, and the residue is extracted with diethyl ether (2 × 25 ml.), and the solid is removed by filtration. The filtrate is evaporated to give a residue that crystallizes on trituration with petroleum ether. The material is recrystallized from dilute acetone to give crystals, m.p. 101°-103°C.

Provenance & Evidence