反应详情

A mixture of 10.0 g. (0.03 mol) of 1-benzyl-4-hydroxy-4-(α,α,α-trifluoro-p-tolyl)piperidine and 1.0 g. of 10% Pd/C in 100 ml. of ethanol containing 2.0 ml. of acetic acid is shaken under hydrogen. The mixture is filtered and the filtrate is evaporated to give a white solid which is dissolved in 50 ml. of water and rendered alkaline by addition of 1N NaOH solution. Filtration gives white crystals, m.p. 136°-138°C.

1. additionA mixture of 10.0 g
2. filtrationThe mixture is filtered
3. customthe filtrate is evaporated
4. customto give a white solid which
5. dissolutionis dissolved in 50 ml
6. filtrationFiltration
7. customgives white crystals, m.p. 136°-138°C.