4-(4-Chlorophenyl)-1,2,3,6-tetrahydropyridine → HCID 21559971, compound

HRID 1578407Notes

Reaction equation

HRID 1578407 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14]Br)[CH2:5]1)(=[O:3])[CH3:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH2:24][CH2:25][NH:26][CH2:27][CH:28]=2)=[CH:19][CH:18]=1>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14][N:26]2[CH2:25][CH:24]=[C:23]([C:20]3[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=3)[CH2:28][CH2:27]2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 1857174-(4-Chlorophenyl)-1,2,3,6-tetrahydropyridineHCID 215599751-[3-(2-bromoethyl)-2,3-dihydro-1H-indol-1-yl]ethanone

Product 1

HCID 21559971HCID 21559971, compound

Procedure

In the manner described in Example 1, reaction of 1-acetyl-3-(2-bromoethyl)indoline with 4-(p-chlorophenyl)-1,2,3,6-tetrahydropyridine gives white crystals, m.p. 116°-118°C., after recrystallization from dilute methanol.

Workup

  1. customgives white crystals, m.p. 116°-118°C.
  2. customafter recrystallization from dilute methanol

Sources & evidence

ORD record
ord-397884d6efef41309ec34435f3c55b59
Source dataset
uspto-grants-1976_02
Patent number
US03936464

Reaction notes

Loading…