HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethyl-4-phenylpiperidine → 1-Acetyl-3-[2-(4-ethyl-4-phenylpiperidino)ethyl]-indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethyl-4-phenylpiperidine | HCID 100846 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 1-[3-(2-bromoethyl)-2,3-dihydro-1H-indol-1-yl]ethanone | HCID 21559975 | — |
| Product | 1-Acetyl-3-[2-(4-ethyl-4-phenylpiperidino)ethyl]-indoline | HCID 21559965 | — |
Reaction Steps
In the manner described in Example 1, treatment of 1-acetyl-3-(2-bromoethyl)indoline with 4-ethyl-4-phenylpiperidine gives an oil. On reaction with molar equivalent of fumaric acid, a crystalline fumarate results. After recrystallization from acetone-hexane it melts at 173°-178°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03936464 |
| Source dataset | uspto-grants-1976_02 |
| ORD ID | ord-cf48f9e71e6e4215a04fb5a8a8172513 |
| Source note | uspto-grants-1976_02 |