p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Conditions

Reaction Steps

A slurry is formed with 5.0 g. (0.025 moles) of L-α-hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid in 50 ml. of ethyl acetate under nitrogen. The slurry is heated to 70°C. and 4 g. (0.028 moles) of p-toluene sulfonic acid monohydrate is added all at once. The mixture which has cooled somewhat is reheated to 70°C. and then allowed to cool to room temperature. The mixture is aged 21/2 hours at room temperature. The product is filtered, washed once with ethyl acetate and then dried in vacuo (20 mm.) at room temperature. The p-toluene sulfonic acid salt of L-α-hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid is obtained in a yield of 7.84 g. or 82 percent of theory.

Provenance & Evidence