Formaldehyde → HCID 54573675, compound

Participants

Reaction Steps

264 Gm (1 mol) of 1-(Diethylphosphonoacetyl)-imidazolidin-2-one and 33 gm of paraformaldehyde (1.1 mol) were dissolved in 2.5 liters of tetrahydrofuran; and after the addition of about 0.3 gm of sodium hydride, the solution was refluxed for one hour. After the solvent had been distilled off, there remained 1-(diethylphosphonoacetyl)-3-hydroxymethylimidazolidin-2-one as a yellowish, viscous liquid. The determination of the total formaldehyde and the free formaldehyde gave a degree of hydroxymethylation amounting to 100%. The compound had the formula ##EQU12##

Provenance & Evidence