Acetic Acid → HCID 54554601, compound

Participants

Reaction Steps

A mixture of 40 parts of 5-(4-amino-1-piperazinyl)-5H-dibenzo[a,d]cycloheptene-10-carbonitrile, 50 parts of 2-pyridinecarboxaldehyde, 3 parts of glacial acetic acid, and 400 parts of 2-propanol is heated at the boiling point under reflux for 5 hours, then refrigerated until precipitation is complete. Insoluble solids are removed by filtration, consecutively washed with absolute ethanol and hexane, and air-dried. Recrystallization of this material from a mixture of chloroform and hexane affords 5-[4-(2-pyridylmethylene)amino-1-piperazinyl]-5H-dibenzo[a,d]cycloheptene- 10-carbonitrile as a light tan solid which, dried in air, melts at 182.5°-184°.

Provenance & Evidence