Acetic Acid → HCID 54509899, compound

Participants

Reaction Steps

A mixture of 30 parts of 5-(4-amino-1-piperazinyl)-5H-dibenzo[a,d]cycloheptene-10-carbonitrile, 21 parts of 6-methyl-2-pyridinecarboxaldehyde, 1 part of glacial acetic acid, and 250 parts of 2-propanol is heated at the boiling point under reflux with stirring for 4 hours, then stripped of solvent by vacuum distillation. The residue is crystallized from a mixture of tetrahydrofuran and hexane to give 5-{4-[(6-methyl-2-pyridylmethylene)amino]-1-piperazinyl}-5H-dibenzo[a,d]cycloheptene-10-carbonitrile as light brown crystals melting at 200°-202°.

Provenance & Evidence