Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(2-Aminophenyl)-2-(methylsulfinyl)ethanone | HCID 14358427 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12435002 | HCID 12435002 | — |
Reaction Steps
A solution of 5.0 g (0.025 mole) of 2'-amino-2-(methylsulfinyl)-acetophenone, 30 ml (0.03 mole) of cold (15°C) 1N hydrochloric acid and 100 ml of cold water cooled to 5°C. A solution of 2.07 g (0.03 mole) of sodium nitrite in 10 ml of water was added over a period of 3 minutes with stirring, keeping the temperature at 5°C. A deep red color developed as yellow solid separated. The mixture was allowed to warm up to 20°C. After 15 minutes at 20° the product was filtered, washed with water, 2-propanol and then ether. Wt 5.0 g (64%) mp. 266°-269°. Recrystallization from N,N-dimethylformamide gave pure, white crystals melting at 274°-276°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03937704 |
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| Source dataset | uspto-grants-1976_02 |
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| ORD ID | ord-818564f6ef65440ca56501f96f172ff0 |
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| Source note | uspto-grants-1976_02 |
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