Acetic Anhydride → HCID 21823684, compound

HRID 1578494Notes

Reaction equation

HRID 1578494 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[N:7]=[C:6]([S:13]([CH3:15])=O)[C:5]2=[O:16].[C:17]([O:20]C(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:20][CH2:15][S:13][C:6]1[C:5](=[O:16])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[N:8]([CH3:12])[N:7]=1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21823683HCID 21823683, compound

Product 1

HCID 21823684HCID 21823684, compound

Procedure

A mixture of 8 g of 6-chloro-1-methyl-3-(methylsulfinyl)-4(1H) cinnolinone and 30 ml of acetic anhydride was refluxed for 21/2 hrs. The resulting solution was allowed to stand at room temperature overnight. The crystalline precipitate was filtered off, washed with Skelly B, and recrystallized from CH3CN, mp. 191°-92°; yield 6 g (65%).

Workup

  1. temperaturewas refluxed for 21/2 hrs
  2. filtrationThe crystalline precipitate was filtered off
  3. washwashed with Skelly B
  4. customrecrystallized from CH3CN, mp. 191°-92°

Sources & evidence

ORD record
ord-d758922fdce3430d8815f3a9accec178
Source dataset
uspto-grants-1976_02
Patent number
US03937704

Reaction notes

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