Sodium Methoxide → HCID 21559385, compound

HRID 1578528Notes

Reaction equation

HRID 1578528 reaction equation
[CH2:1]([N:5]1[CH2:9][CH2:8][O:7][CH:6]1[CH:10]([CH3:12])[CH3:11])[CH:2]1[O:4][CH2:3]1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][CH2:3][CH:2]([OH:4])[CH2:1][N:5]1[CH2:9][CH2:8][O:7][CH:6]1[CH:10]([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 214849713-[(Oxiran-2-yl)methyl]-2-(propan-2-yl)-1,3-oxazolidine

Product 1

HCID 21559385HCID 21559385, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into a 500 ml., three-neck flask equipped with a mechanical stirrer, dropping funnel and condenser with a drying tube was charged 171 g. (1 mole) of 3-glycidyl-2-isopropyloxazolidine and 250 cc. of absolute methanol. While stirring at room temperature an equivalent amount of sodium methoxide (25% solution methanol) was added over a 30 minute period. The mixture was stirred an additional two hours after addition was completed. The solvent was then removed in vacuo to afford 3-(3-methoxy-2-hydroxypropyl)-2-isopropyl-1,3-oxazolidine.

Workup

  1. custom, three-neck flask equipped with a mechanical stirrer
  2. additionwas charged 171 g
  3. additionwas added over a 30 minute period
  4. additionafter addition
  5. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-aa8e0e68ebd1421590a413bab1fc1e6d
Source dataset
uspto-grants-1976_02
Patent number
US03937716

Reaction notes

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