Methyl iodide → 1-Propanone, 2-methoxy-1,2-diphenyl-

HRID 1578548Notes

Reaction equation

HRID 1578548 reaction equation
[CH3:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([OH:11])[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+].[CH3:20]I>O>[CH3:20][O:11][C:2]([CH3:1])([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 3446932-hydroxy-1,2-diphenyl-1-propanone

Product 1

HCID 35415691-Propanone, 2-methoxy-1,2-diphenyl-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Portions of 2.85 g α-methyl-benzoin are dissolved in a nitrogen atmosphere in 25 ml of solvent and mixed with 5.5 ml of a 10% by weight sodium hydroxide solution and then with 0.8 ml methyl iodide, while maintaining a temperature of 25°C. After stirring for 2 hours, the reaction products are poured into water, isolated and analysed by NMR-spectroscopy.

Workup

  1. customisolated

Sources & evidence

ORD record
ord-b100ea96fa1e4d71b5f0f5dab6465d77
Source dataset
uspto-grants-1976_02
Patent number
US03937722

Reaction notes

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