HCID 21559725, compound → HCID 68147443, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 105 g (1.2 mol) of formyl acetic anhydride and 40 ml of pyridine cooled to -10°C was added 16.5 g (0.1 mol) of 2,4-dihydroxybenzoylacetonitrile. This mixture was stirred overnight, allowing the reaction to warm to room temperature. The mixture was evaporated in vacuo and the residue was triturated with ethanol and filtered to give 23.3 g of crude material. Recrystallization of this solid from absolute ethanol gave 5.3 g of 7-hydroxy-4-oxo-4H-1-benzopyran-3 -carbonitrile acetate, mp 178°-180°C.

Provenance & Evidence