Water → HCID 68135586, compound

Participants

Reaction Conditions

Reaction Steps

trans-2-(4-Cyclohexyl-3-hydroxy-1-butenyl)-5-[(tetrahydropyran-2-yl)oxy]cyclopentaneheptanoic acid methyl ester acetate (44 g), described in Example 8, is dissolved in acetic acid (426 ml), water (212 ml) and tetrahydrofuran (35.7 ml). The mixture is stirred at 60°C (bath temperature) for 3 hr. The solvent is removed under reduced pressure. The residue is taken up in ether. The ether solution is washed with water, dried and evaporated to yield trans-2-(4-cyclohexyl-3-acetoxy-1-butenyl)-5-hydroxycyclopentaneheptanoic acid methyl ester νmaxCHCl3 3,451, 1,730, 1,240 cm-1.

Provenance & Evidence