M-Cresol → Deferiprone

Participants

Reaction Steps

Using the method described in Example 8, 240 g of m-cresol are mixed with 50.4 g of 4,4'-diisocyanatodiphenyl ether followed by 70.6 g of 4,4'-bis-α-chloroacetamidodiphenylether at 120°C and the mixture is then reacted at 185°C for 14 hours. 346 g of an approximately 30% polyhydantoin solution which has a chlorine content below 0.2% and a viscosity of 12460 cP20°C are obtained. Precipitation of this solution in methanol yields 210 g of a polyhydantoin with a nitrogen content of 10.4% and a chlorine content below 0.2%. The hydantoin structure is in both cases confirmed by the IR absorption bands at 1700 and 1755 cm-1.

Provenance & Evidence