Acetic Acid → HCID 68138826, compound

Participants

Reaction Steps

1.7 g (0.016 mole) of 1-methyl-4-piperidone and 3 ml. of glacial acetic acid are added to a solution of 2.7 g (0.014 mole) of 1-(2-amino-4-chloro-phenyl) pyrrole, Example 13(b), in 50 ml. of absolute ethanol. The solution is refluxed for 36 hours and concentrated, and the residue dissolved in water. The aqueous solution is filtered, and the filtrate is basified. A solid precipitates, is filtered, and dried. The solid is dissolved in ether and ethereal-hydrogen chloride is added. The resulting precipitate is filtered, dried, and recrystallized from methanol to give 7-chloro-4,5-dihydro-1'-methylspiro-[pyrrolo (1,2-a)quinoxaline-4,4'-piperidine] hydrochloride, m.p. 297°-298° C.

Provenance & Evidence