3-Hydroxypyridine → HCID 21558649, compound

Participants

Reaction Steps

Sodium hydride (1.32g.) was added portionwise under an atmosphere of nitrogen during 30 minutes, to a stirred solution of 3-hydroxypyridine (2.85g.) in dry dimethylsulphoxide (28ml.) cooled to below 25°C. When reaction ceased, 1,6-dibromohexane (3.66g.) was added dropwise with stirring and cooling, and the resulting mixture was stirred a further 31/2 hours. The mixture was poured into ice-water, and the precipitated product was filtered off and crystallised from petroleum ether (b.p.60°- 80°C.), to give 1,6-bis-pyrid-3-yloxyhexane, m.p. 85°C.

Provenance & Evidence