Estrone → Estrone

Participants

Reaction Steps

Into a mixture of 1 g of estrone, 0.5 ml of dimethyl sulfate and 5 ml of tetrahydrofuran, 6 ml of 10% aqueous solution of potassium hydroxide was added over a period of one hour. The reaction temperature was maintained at 15° - 20°C during the addition. The resulting mixture was stirred for one hour to complete the etherification. Then, 6 ml of water was added, and tetrahydrofuran was distilled under atmospheric pressure. The crystals which formed during the distillation were filtered from the cooled reaction mixture, washed with water and dried to obtain 1.048 g of the 100% purity methyl ether of estrone in a 99.7% yield.

Provenance & Evidence