Methanol → Estrone

Participants

Reaction Steps

Into a mixture of 20 ml of methanol and 16 ml of 30% aqueous solution of potassium hydroxide, 1.0 g of estrone was dissolved and the mixture was cooled in an ice bath and stirred while 4 ml of dimethyl sulfate was added. Stirring was continued for 2 hours. Water was added to the reaction mixture and the crystals which precipitated during the addition of water were filtered, washed with water and dried to obtain 0.341 g of the 96.3% purity methyl ether of estrone in a 34.2% yield.

Provenance & Evidence