3-Bromo-5,6-dimethoxy-phthalide → 5,6-Dimethoxyphthalide benzylpenicillin

Participants

Reaction Steps

Potassium-benzylpenicillin (2.73 g., 0.00734 mole) was stirred in dry D.M.F. (100 ml.) with 3-bromo-5,6-dimethoxyphthalide (2.0 g., 0.00734 mole) for 12 hours. The mixture was poured into iced water (2 lits) with vigorous stirring and the solid filtered, dried and crystallised from isopropanol.

Provenance & Evidence