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Isopropanol → Diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| 反応物 | Ethylideneacetoacetic acid ethyl ester | HCID 53428592 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | HCID 12391086 | 59% |
反応手順
Upon heating a solution of 15.6 g of ethylideneacetoacetic acid ethyl ester and 13.0 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 2 hours, 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 140°C (isopropanol) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03939171 |
| 出典データセット | uspto-grants-1976_02 |
| ORD ID | ord-0038fa81162f48258360b9f0f1d0f94e |
| 出典メモ | uspto-grants-1976_02 |