Ethanol → 2-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester

反応式

C(OC(=O)C[C:6]([CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17])=[O:7])C.[CH:20]([O:23][C:24](=[O:29])[CH2:25][C:26](=[NH:28])[NH2:27])([CH3:22])[CH3:21].[CH:30]([OH:33])(C)[CH3:31].[CH2:34](O)[CH3:35]>>[CH2:30]([O:33][C:6]([C:8]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N+:16]([O-:18])=[O:17])[C:25]([C:24]([O:23][CH:20]([CH3:22])[CH3:21])=[O:29])=[C:26]([NH2:27])[NH:28][C:34]=1[CH3:35])=[O:7])[CH3:31]

参加物

反応物 4

HCID 702Ethanol

HCID 3776Isopropanol

HCID 12391080Amidinoacetic acid isopropyl ester

HCID 53923751Ethyl 2-nitrobenzylidene-acetoacetate

生成物 1

HCID 706351172-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester収率 39%

実験手順

Boiling a solution of 13.2 g of 2-nitrobenzylideneacetoacetic acid ethyl ester and 7.2 g of amidinoacetic acid isopropyl ester in 100 ml of ethanol for 6 hours yields 2-amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-ethyl ester of melting point 139°C (isopropanol).

後処理

customfor 6 hours

出典と根拠

ORDレコード: ord-bfafe472e2d7414ab22ccbe3509a5fbc
出典データセット: uspto-grants-1976_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03939171

反応ノート

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