Acetic Anhydride → HCID 53660973, compound

Participants

Reaction Steps

To a mixture of 3,7,11,15,19-pentamethyl-2,6,14,18-eicosatetraene-1,10-diol (3.75 g) in pyridine (1 ml) while cooling with ice, acetic anhydride (1.53 g) is dropwise added in 15 minutes, and then stirring is continued for 40 minutes. The reaction mixture is poured into ice water and extracted with ether. The ether extract is washed with water, dried and evaporated. The residue (3.9 g) is purified by chromatography on silica gel (40 g) using benzene to give 1-acetoxy-3,7,11,15,19-pentamethyl-2,6,14,18-eicosatetraen-10-ol (3.1 g).

Provenance & Evidence