Potassium Hydroxide → HCID 53789991, compound

Participants

Reaction Steps

As in Example 7 (4), ethyl 3,7,11,15,19-pentamethyl-6,10,14,18-eicosatetraen-2-one-1-carboxylate (4.3 g) and 1-bromo-2,6,10,14,18-pentamethyl-20-acetoxy-2,6,10,14,18-eicosapentaene (4.8 g) are reacted in ether (59 ml) in the presence of sodium hydride (0.26 g). The product is added to a solution of potassium hydroxide (1.68 g) in ethanol (32 ml), and the resultant mixture is treated as in Example 1 (4) to give 3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,26,30,34,38-tetracontanonaen-22-on-1-ol (6.8 g). IR: 3400, 1000 cm-1 (OH); 1705 cm-1 (C=O); 1668 cm-1 (C=C). NMR (carbon tetrachloride): δ 1.59 (s), 1.66 (s), 2.01 (m), 2.7 (m), 4.1 (m), 5.05 (m).

Provenance & Evidence