HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 21416290, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Bromohexane | HCID 8101 | — |
| Reactant | HCID 21416279 | HCID 21416279 | — |
| Reactant | HCID 21416287 | HCID 21416287 | — |
| Product | HCID 21416290 | HCID 21416290 | — |
Reaction Steps
5-(3',5' -di-tert-butyl-4'-hydroxyphenylethyl)hydantoin is treated with morpholine and formaldehyde according to the procedure of O. O Orazi and R. A. Corral, Tetrahedron, 15, 93 (1961) to prepare the corresponding 3-N-morpholinomethyl-5-(3',5' -di-tert-butyl-4'-hydroxyphenylethyl)hydantoin. This material is then alkylated in the 1-position with 1-bromohexane as described in Example 25. The morpholinomethyl group is removed by subsequent hydrolysis according to the procedure of O. O. Orazi and R. A. Corral, Experientia, 21, 508 (1965) to give 5-(3',5' -di-tert-butyl-4'-hydroxyphenylethyl)-1-n-hexylhydantoin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03939175 |
| Source dataset | uspto-grants-1976_02 |
| ORD ID | ord-fcb626fa2a8f4543934f17f8e275f4aa |
| Source note | uspto-grants-1976_02 |