Sodium Hydroxide → HCID 54084847, compound

HRID 1578845Notes

Reaction equation

HRID 1578845 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54131094HCID 54131094, compound

Product 1

HCID 54084847HCID 54084847, compound

Procedure

The mixture of 2.2 g of 4-(4-acetamidophenylmercapto)-3-benzylamino-5-sulfamoylbenzoic acid and 22 ml of 2N aqueous sodium hydroxide is refluxed for one hour under nitrogen. After cooling it is filtered, the filtrate acidified with glacial acetic acid to pH = 4. The precipitate formed is filtered off and recrystallized from 50% aqueous ethanol, to yield the 4-(4-aminophenylmercapto)-3-benzylamino-5-sulfamoylbenzoic acid melting at 254°-256°.

Workup

  1. temperatureis refluxed for one hour under nitrogen
  2. temperatureAfter cooling it
  3. filtrationis filtered
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. customrecrystallized from 50% aqueous ethanol

Sources & evidence

ORD record
ord-b5c91f5e82784c8fad0cd1d72f8ea3c8
Source dataset
uspto-grants-1976_02
Patent number
US03939267

Reaction notes

Loading…