Sodium Hydroxide → HCID 54129660, compound

HRID 1578847Notes

Reaction equation

HRID 1578847 reaction equation
C([NH:4][C:5]1[CH:34]=[CH:33][C:8]([O:9][C:10]2[C:18]([S:19](=[O:25])(=[O:24])[NH:20]C(=O)C)=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=2[NH:26][CH2:27][C:28]2[O:32][CH:31]=[CH:30][CH:29]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:18]([S:19](=[O:24])(=[O:25])[NH2:20])=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=2[NH:26][CH2:27][C:28]2[O:32][CH:31]=[CH:30][CH:29]=2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54348889HCID 54348889, compound

Product 1

HCID 54129660HCID 54129660, compound

Procedure

The mixture of 1.1 g of 4-(4-acetamidophenoxy)-3-furfurylamino-5-acetylsulfamoylbenzoic acid and 11 ml of 2N aqueous sodium hydroxide is refluxed for two hours under nitrogen. After cooling to room temperature it is filtered, the filtrate acidified with glacial acetic acid to a pH of 4- 5 and the precipitate formed filtered off. It is recrystallized from 70% aqueous ethanol, to yield the 4-(4-aminophenoxy)-3-furfurylamino-5-sulfamoylbenzoic acid melting at 233°-235°.

Workup

  1. temperatureis refluxed for two hours under nitrogen
  2. filtrationis filtered
  3. customthe precipitate formed
  4. filtrationfiltered off
  5. customIt is recrystallized from 70% aqueous ethanol

Sources & evidence

ORD record
ord-b2ec679ba11245a7a818ef3333483463
Source dataset
uspto-grants-1976_02
Patent number
US03939267

Reaction notes

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